Effect of Thyroid Hormone on Radiation Lethality

Abstract

The effect of thyroid hormone in increasing radiation lethality in mice was equivalent to about 100r and the critical period of susceptibility to this thyroid effect extended through the second week after irradiation. Dinitrophenol also increased radiation deaths. Thiouracil and propylthiouracil failed to protect. A yeast supplement failed to prevent the thyroid effect. Weights of adrenal, lymphoid tissue and kidney were detd. and blood studies made. Leucocytes and hemoglobin were more depressed in thyroid-treated than in control mice after sublethal irradiation.