A Comparative Proton Magnetic Resonance Study of the Molecular Conformation of Uracil and 6-Aza Uracil Nucleosides and Nucleotides

Abstract

Proton magnetic resonance data for uridine and uridine-5′-monophosphate, and the corresponding 6-azauracil analogs, are presented and discussed in terms of their overall three dimensional conformations in aqueous solution. The data reveal a destabilizing influence of the 6-aza base upon the gog and g′–g′ conformation of the ribose phosphate moiety.