Hypoparathyroidism: A Possible Cause of Osteomalacia

Abstract

A 17 yr old man with longstanding hypocalcemia and hyperphosphatemia presented with incapacitating bone pain and progressive weakness and bowing of the legs. The serum abnormalities were due to idiopathic hypoparathyroidism as evidenced by a decreased serum concentration of parathyroid hormone and an appropriate rise in urinary cyclic AMP and phosphate excretion, and serum Ca concentration, in response to exogenously administered parathyroid extract. The serum concentration of 1,25-dihydroxycholecalciferol was appropriately decreased. The bone findings were due to osteomalacia as documented by physical findings, bone roentgenograms and bone biopsy. Normal renal tubular function, blood pH and serum concentration of 25-hydroxycholecalciferol and elevated serum alkaline phosphatase excluded the common causes of osteomalacia. The data are consistent with the hypothesis that lack of parathyroid hormone causes both hypocalcemia and a decreased serum concentration of 1,25-dihydroxycholecalciferol which, in turn, limit the availability of Ca and cause defective synthesis of bone matrix resulting in abnormal mineralization.