Combination Chemotherapy with cis-Diamminedichloroplatinum (II) and Bleomycin in Tumors of the Head and Neck

Abstract

28 patients with head and neck tumors not suitable for definitive treatment with radiation or surgery were treated with cis-diamminedichloroplatinum (II) and bleomycin in combination. Of 24 adequately treated patients, there were 3 partial remissions lasting for 3, 3, and 6 months, respectively. Toxicity of the regimen as given was substantial; 13 patients showed some evidence of nephrotoxicity and there were 2 drug deaths related to progressive renal failure. 1 patient developed bleomycin pulmonary toxicity.