Functional Characterization and Developmental Regulation of Mouse Telomerase RNA
- 1 September 1995
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 269 (5228), 1267-1270
- https://doi.org/10.1126/science.7544492
Abstract
Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA. Alteration of the template region in vivo generated altered telomerase products. The shorter template regions of the mouse and other rodent telomerase RNAs could account for the shorter distribution of products (processivity) generated by the mouse enzyme relative to the human telomerase. Amounts of telomerase RNA increased in immortal cells derived from primary mouse fibroblasts. RNA was detected in all newborn mouse tissues tested but was decreased during postnatal development.Keywords
This publication has 12 references indexed in Scilit:
- Runaway telomere elongation caused by telomerase RNA gene mutationsNature, 1995
- Specific Association of Human Telomerase Activity with Immortal Cells and CancerScience, 1994
- TLC1 : Template RNA Component of Saccharomyces cerevisiae TelomeraseScience, 1994
- Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.Genes & Development, 1994
- Compilation of small RNA sequencesNucleic Acids Research, 1992
- Hypervariable ultra-long telomeres in miceNature, 1990
- In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAsNature, 1990
- Functional Evidence for an RNA Template in TelomeraseScience, 1990
- A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesisNature, 1989
- Identification of a specific telomere terminal transferase activity in tetrahymena extractsCell, 1985