Inhibitors of genetic recombination in pneumococci.
- 1 January 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (1), 296-299
- https://doi.org/10.1073/pnas.74.1.296
Abstract
Treatment of transformable pneumococci [Streptococcus pneumoniae] with DNA-intercalating agents shortly after the uptake of DNA molecules inhibited the appearance of genetic transformants. The same drug treatments applied 20 min after DNA uptake were ineffective. Ethidium bromide, proflavin, daunomycin, actinomycin D and platinum red were effective inhibitors. Donor DNA molecules reisolated from the drug-treated bacteria appeared to be associated with the resident DNA in an abnormal manner and had poor transforming activity.This publication has 22 references indexed in Scilit:
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