Chiral separation of 3,4‐methylenedioxymeth‐ amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy
- 19 March 2003
- journal article
- research article
- Published by Wiley in Electrophoresis
- Vol. 24 (6), 1097-1104
- https://doi.org/10.1002/elps.200390128
Abstract
The R-(–)- and S-(+)-isomers of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA) were prepared, identified by gas chromatography/mass spectrometry (GC/MS) and then used as standards in a series of capillary electrophoresis (CE) experiments. Using these R-(–)- and S-(+)-isomers, the distribution of (RS)-MDA and (RS)-MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of β-cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.Keywords
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