Crystal structure of cyclin-dependent kinase 2
- 17 June 1993
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 363 (6430), 595-602
- https://doi.org/10.1038/363595a0
Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4Å resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix—loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.Keywords
This publication has 54 references indexed in Scilit:
- Purification and Crystallization of Human Cyclin-dependent Kinase 2Journal of Molecular Biology, 1993
- Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinaseNature, 1991
- Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseScience, 1991
- The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localizationCell, 1989
- OncogenesCurrent Opinion in Cell Biology, 1989
- Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinaseJournal of the American Chemical Society, 1988
- Chemical mechanism of the adenosine cyclic 3',5'-monophosphate dependent protein kinase from pH studiesBiochemistry, 1987
- Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucoseCell, 1986
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical featuresBiopolymers, 1983
- Solvent content of protein crystalsJournal of Molecular Biology, 1968