Immune function during ageing in man: relation between serological abnormalities and cellular immune status
- 1 June 1983
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 13 (3), 209-214
- https://doi.org/10.1111/j.1365-2362.1983.tb00089.x
Abstract
In a group of 176 apparently healthy aged people living at home (age range 62-86 yr) the prevalences of monoclonal Ig and of autoantibodies did not differ from those found in other studies, but remarkably 38% of the people studied had cold lymphocytotoxic antibodies. The occurrence of serological abnormalities showed no age dependency. The participants were grouped according to serological abnormalities. The various groups showed no differences in peripheral blood mononuclear cell composition (concentration of B lymphocytes and T lymphocytes or of T lymphocyte subsets with OKT 4 and OKT 8 phenotype) or function (lymphocyte stimulation with phytohemagglutinin, concanavalin A, pokeweed mitogen and antigen cocktail). Compared with a control group of young blood donors, the lymphocyte stimulation responses tended to be lower in the old age groups. As measured in this study, humoral abnormalities during aging are apparently not associated with changes in B and T lymphocyte subsets or function.Keywords
This publication has 20 references indexed in Scilit:
- Blood T‐Lymphocyte Functions in Healthy Adults in Relation to AgeScandinavian Journal of Haematology, 1982
- Incidence of Paraproteinaemia in Blood DonorsVox Sanguinis, 1980
- Age-dependent changes in human peripheral blood B cells and T-cell subsets: Correlation with mitogen responsivenessClinical Immunology and Immunopathology, 1980
- Abnormalities of Immunoregulatory T Cells in Disorders of Immune FunctionNew England Journal of Medicine, 1979
- Immunofluorescent studies of the development of pre‐B cells, B lymphocytes and immunoglobulin isotype diversity in humansEuropean Journal of Immunology, 1977
- Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.The Journal of Experimental Medicine, 1977
- An improved rosetting assay for detection of human T lymphocytesJournal of Immunological Methods, 1974
- The Concept of Immunological SurveillancePublished by S. Karger AG ,1969
- SEROTYPING FOR HOMOTRANSPLANTATION XVIII. REFINEMENT OF MICRODROPLET LYMPHOCYTE CYTOTOXICITY TESTTransplantation, 1968
- Frequency of “Abnormal” Serum Globulins (M‐Components) in the AgedActa Medica Scandinavica, 1963