COMPARATIVE CLINICAL-STUDY OF PROTEIN SAP (AMYLOID P-COMPONENT) AND C-REACTIVE PROTEIN IN SERUM
- 1 January 1978
- journal article
- research article
- Vol. 32 (1), 119-124
Abstract
The serum concentration of protein SAP was measured in a substantial series of normal individuals and patients with various diseases. The results were contrasted with the levels of the related protein C-reactive protein (CRP). The mean concentration of protein SAP was 43 .+-. 14 .mu.g/ml in 76 normal men, 33 .+-. 10 .mu.g/ml in 86 normal women and 4 .+-. 2 .mu.g/ml in 36 normal cord sera. Unlike CRP, which is a major acute phase reactant, protein SAP was only slightly elevated in inflammatory and neoplastic diseases in which CRP was greatly increased. The level of protein SAP was significantly depressed in patients with hepatic disease, suggesting that its measurement might be of value in their management.This publication has 15 references indexed in Scilit:
- Amino acid sequence similarities between amyloid P component C1t and CRPNature, 1977
- ISOLATION OF AMYLOID P COMPONENT (PROTEIN AP) FROM NORMAL SERUM AS A CALCIUM-DEPENDENT BINDING PROTEINThe Lancet, 1977
- Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins).Proceedings of the National Academy of Sciences, 1977
- Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.BMJ, 1977
- EFFECTS OF C-REACTIVE PROTEIN ON PLATELET-FUNCTION .1. INHIBITION OF PLATELET-AGGREGATION AND RELEASE REACTIONS1976
- Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin.1974
- [Human serum proteins with affinity for carboxymethyl cellulose. 3. Physico-chemical and immunological characterization of a metal-binding 9.5S- 1-glycoprotein (CM-protein 3)].1972
- Clinical observation on the origin of C-reactive protein in bloodClinical Biochemistry, 1971
- Immunoassay of P-Component in Amyloidotic Sera.Experimental Biology and Medicine, 1967
- THE LIVER AS THE SITE OF C-REACTIVE PROTEIN FORMATIONThe Journal of Experimental Medicine, 1966