Insulin Resistance of Protein Metabolism in Type 2 Diabetes
Open Access
- 1 January 2008
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 57 (1), 56-63
- https://doi.org/10.2337/db07-0887
Abstract
OBJECTIVE—We previously demonstrated that 1) obesity impairs and 2) sex influences insulin sensitivity of protein metabolism, while 3) poor glycemic control in type 2 diabetes accelerates protein turnover in daily fed-fasted states. We hypothesized that type 2 diabetes alters the insulin sensitivity of protein metabolism and that sex modulates it.Keywords
This publication has 43 references indexed in Scilit:
- Lower-body fat mass as an independent marker of insulin sensitivity—the role of adiponectinInternational Journal of Obesity, 2005
- Defective Nonoxidative Leucine Degradation and Endogenous Leucine Flux in Cirrhosis During An Amino Acid InfusionHepatology, 1998
- Skeletal muscle proteolysis is reduced in noninsulin-dependent diabetes mellitus and is unaltered by euglycemic hyperinsulinemia or intensive insulin therapyJournal of Clinical Endocrinology & Metabolism, 1995
- Hyperinsulinemia prevents prolonged hyperglycemia after intense exercise in insulin-dependent diabetic subjectsJournal of Clinical Endocrinology & Metabolism, 1994
- Effect of NIDDM on the kinetics of whole-body protein metabolismDiabetes, 1994
- Effects of insulin and amino acids on leg protein turnover in IDDM patientsDiabetes, 1991
- Leucine metabolism in IDDM. Role of insulin and substrate availabilityDiabetes, 1990
- Leucine metabolism in type II diabetes mellitusDiabetes, 1986
- Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism.Journal of Clinical Investigation, 1986
- Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitusDiabetes, 1984