Effects of Dopamine on Kidney Function and on the Adenyl Cyclase Phosphodiesterase System in Man
- 1 February 1976
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 6 (1), 131-137
- https://doi.org/10.1111/j.1365-2362.1976.tb00503.x
Abstract
Clearance studies were made to determine the influence of i.v. infusions of dopamine (between 2.5 and 3.5 .mu.g kg-1 min-1) on renal function and on the adenyl cyclase phosphodiesterase system in 11 patients with chronic renal disease. Glomerular filtration rate (+19%), effective renal plasma flow (+29%), Na (+199%) and K (+40%) clearances were significantly increased. These effects were associated with a stimulation of the adenyl cyclase phosphodiesterase system demonstrated by an increase of cyclic AMP in plasma and urine. Dopamine probably affects renal function by activating the adenyl cyclase phosphodiesterase system.Keywords
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