Influenza virus‐specific cytotoxic T cells in man; induction and properties of the cytotoxic cell
- 1 October 1978
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 8 (10), 705-711
- https://doi.org/10.1002/eji.1830081007
Abstract
Human peripheral blood lymphocytes have been sensitized in vitro to influenza virus antigen. After an induction period of 4–14 days, cytotoxic cells which lyse autologous influenza virus-infected lymphoid cells could be demonstrated. The cytotoxic cell is a T lymphocyte which shows specificity for sensitizing influenza virus type A or B. It cannot distinguish between major subtypes of influenza A virus. The use of virus-infected normal lymphoid cells as target cells overcame the difficulties of nonspecific killing encountered with some transformed cells.Keywords
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