Adaptation of Type I Strain of Poliomyelitis Virus to Mice and Cotton Rats
- 1 June 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 86 (2), 238-244
- https://doi.org/10.3181/00379727-86-21061
Abstract
A mixture of 2 strains (Sickle and Mahoney strains) of type I poliomyelitis virus was adapted to mice (PRI strain) and to cotton rats, following passages through tissue cultures. Several sublines were obtained, some of which could be propagated in rodents either by the intraspinal or the intracerebral route. The cytopathic titer in tissue culture of the various sublines was of similar magnitude but the infectivity for mice and cotton rats varied considerably. A subline was obtained which proved to be completely avirulent for rhesus and cynomolgus monkeys.Keywords
This publication has 5 references indexed in Scilit:
- Adaptation of Type I Poliomyelitis Virus to MiceExperimental Biology and Medicine, 1953
- STUDIES ON POLIOMYELITIS VIRUSES IN CULTURES OF MONKEY TESTICULAR TISSUE1American Journal of Epidemiology, 1952
- THE USE OF ADJUVANTS TO FACILITATE STUDIES ON THE IMMUNOLOGIC CLASSIFICATION OF POLIOMYELITIS VIRUSES123American Journal of Epidemiology, 1951
- Nutrition of Animal Cells in Tissue Culture. I. Initial Studies on a Synthetic Medium.,Experimental Biology and Medicine, 1950
- THE VIRUS, THE NERVE CELL, AND PARALYSIS - A STUDY OF EXPERIMENTAL POLIOMYELITIS IN THE SPINAL CORD1948