Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro
- 18 July 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4454), 394-396
- https://doi.org/10.1126/science.7384811
Abstract
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.Keywords
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