Hydrogen peroxide as a signal controlling plant programmed cell death

Abstract

Hydrogen peroxide (H₂O₂) has established itself as a key player in stress and programmed cell death responses, but little is known about the signaling pathways leading from H₂O₂ to programmed cell death in plants. Recently, identification of key regulatory mutants and near-full genome coverage microarray analysis of H₂O₂-induced cell death have begun to unravel the complexity of the H₂O₂ network. This review also describes a novel link between H₂O₂ and sphingolipids, two signals that can interplay and regulate plant cell death.