A COMPARISON OF THE EFFECTS OF NIFEDIPINE AND VERAPAMIL ON RAT VAS DEFERENS
Open Access
- 1 June 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 73 (2), 321-323
- https://doi.org/10.1111/j.1476-5381.1981.tb10424.x
Abstract
Nifedipine preferentially blocks contractions of the prostatic end of the rat vas deferens to single pulse field stimulation, leaving the epididymal end largely unaffected. This action is not due entirely to antagonism of calcium influx. Verapamil unexpectedly potentiated the responses of the prostatic portion, and antagonized those of the epididymal end. The use of nifedipine may, therefore, allow investigations of adrenergic mechanisms on this tissue to be studied without the complications of non-adrenergic transmission.Keywords
This publication has 4 references indexed in Scilit:
- Adrenergic and 'non‐adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus.The Journal of Physiology, 1978
- An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferensThe Journal of Physiology, 1977
- Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth MuscleAnnual Review of Pharmacology and Toxicology, 1977
- Verapamil blockade of slow Na+ and Ca++ responses in myocardial cells.1974