EFFECT OF URINARY pH AND NICOTINE EXCRETION RATE ON PLASMA NICOTINE DURING CIGARETTE SMOKING AND CHEWING NICOTINE GUM
Open Access
- 1 April 1978
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 5 (4), 293-297
- https://doi.org/10.1111/j.1365-2125.1978.tb01710.x
Abstract
1 Plasma nicotine levels produced by chewing nicotine gum were compared with those obtained by cigarette smoking under conditions of controlled urinary pH. 2 Although absorption was slower, plasma levels comparable to cigarette smoking were built up on 4 mg (but not 2 mg) nicotine gum. 3 Urinary excretion of nicotine was influenced markedly by pH and the rate of urine flow. 4 Plasma nicotine was higher under alkaline compared to acidic conditions (P < 0.001) but the rate of urinary nicotine excretion appeared to have little effect on the plasma level.Keywords
This publication has 12 references indexed in Scilit:
- Plasma nicotine levels after cigarette smoking and chewing nicotine gum.BMJ, 1976
- Absorption and metabolism of nicotine from cigarettes.BMJ, 1975
- A substitute for tobacco smokingPsychopharmacology, 1973
- A possible relation between pKa1 and lipid solubility and the amounts excreted in urine of some tobacco alkaloids given to manJournal of Pharmacy and Pharmacology, 1972
- The effect of smoking on nicotine metabolism in vivo in manJournal of Pharmacy and Pharmacology, 1971
- The analysis of nicotine-1‘-N-oxide in urine, in the presence of nicotine and cotinine, and its application to the study of in vivo nicotine metabolism in manJournal of Pharmacy and Pharmacology, 1971
- CIRCULATORY EFFECTS OF NICOTINE AEROSOL INHALATIONS AND CIGARETTE SMOKING IN MANThe Lancet, 1967
- Determination of Nicotine and its Metabolite, Cotinine, in Urine by Gas ChromatographyNature, 1966
- Significance of Smoking in Investigations of Urinary Excretion Rates of Amines in ManNature, 1965