Properties of the in vitro soluble RNA methylase activity of hamster tumors induced by adenovirus-12

Abstract

Certain properties of the tRNA methylases from hamster tumor tissue induced by adenovirus-12, hamster liver, and hamster connective tissue are described. The three enzyme extracts are shown to possess different substrate specificities, different responses to the presence of ammonia ions, different pH optima, and different stabilities on storage.Evidence indicates that the increased tRNA methylase in tumor extracts is not related to the T-antigen found in tumors induced by adenovirus-12.