Typing for RhLA-D in rhesus monkeys: II. Genetics of the D antigens and their association with DR antigens in a population of unrelated animals1

Abstract

A population of 94 unrelated rhesus monkeys was typed for MLC [mixed lymphocyte culture] antigens using 38 homozygous typing cells which define 10 RhLA-D specificities. The 10 D specificities are alleles of a single locus, the gene frequencies of which are in Hardy-Weinberg equilibrium. The association between the cellularly defined D and the serologically defined DR antigens in the population was usually high, confirming the close relationship between D and DR antigens. Two new associations were found, between the D-locus antigens 9 and 10 and the serologically defined B-cell antigens in 109 and 101, respectively. This observation confirms prior speculations that the latter 2 antigens may belong to the DR series.