Glycoprotein Properties of the Solubilized Atrial Muscarinic Acetylcholine Receptor
- 1 May 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (5), 1414-1420
- https://doi.org/10.1111/j.1471-4159.1983.tb00840.x
Abstract
The muscarinic acetylcholine receptor from porcine atria exhibits sialoglycoprotein characteristics based on its sensitivity to neuraminidase digestion and its ability to interact specifically with lectin affinity resins when solubilized with a digitonin/cholate mixed detergent system. Differential lectin binding properties of the neuraminidase-treated and untreated receptor suggest that high-affinity binding to immobilized wheat germ agglutinin is accomplished through the presence of both terminal sialic acid and internal N-acetylglucosamine or its β(1 → 4)-linked oligomers.Keywords
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