Tremorgenic toxins from penicillia. II. A new tremorgenie toxin, tremortin B, from Penicillium palitans

Abstract

A new tremorgenic mycotoxin, tremortin B, was found in the solvent extract of Penicillium palitans mycelium. Tremortins A and B were purified by column chromatography on Florisil followed by Sephadex LH₂₀, and recrystallized from several solvents. Tremortin B was determined to be C₃₇H₄₅NO₅.The LD₅₀ of A is 1.05 mg and B, 5.84 mg/kg mouse. A third potential tremorgen, tremortin C, has also been isolated and purified, but so far the yield is insufficient to determine its characteristics.