Renal Pressor System in Hypertension

Abstract

Hypertensin has been found in the circulating arterial blood in dogs with experimental renal hypertension and in human beings with essential hypertension. Two different chemical forms of the material have been obtained in purified form and their chemical constitution determined. The decapetide hypertensin I is the initial product of the action of renin on its substrate. This material is transformed to the vasoconstrictor octapeptide hypertensin II by a chloride activated enzyme of the plasma.