The Effect of the Injection of Tetanus Toxin into the Central Nervous System of Rabbits

Abstract

Summary: Tetanus toxin injected into the medulla oblongata of rabbits is approximately 1000 times as effective (measured by the period of survival) as toxin injected intravenously. The effectiveness of the injected toxin is progressively less as the following sites are employed—lumbar cord; cerebrospinal fluid and cerebral hemisphere (approximately equal); blood stream and gastrocnemius muscle.