Characterization of a regulatory region upstream of the ADR2 locus of S. cerevisiae
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 300 (5894), 724-728
- https://doi.org/10.1038/300724a0
Abstract
In vitro mutagenesis was used to identify a DNA sequence required for glucose regulation of the ADR2 locus of S. cerevisiae. This region, located between 200 and 1000 base pairs upstream of the structural gene for ADHII, was identified by genetic and biochemical analysis as the site of ADR3, a cis-acting regulatory locus. If this region is deleted, ADR2 is no longer repressed by glucose. Moreover, if the sequence is excised and ligated in front of the ADC1 gene, it puts that gene under glucose control.This publication has 27 references indexed in Scilit:
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