Functional significance of long non-coding RNAs in breast cancer
- 20 July 2014
- journal article
- review article
- Published by Springer Nature in Breast Cancer
- Vol. 21 (5), 515-521
- https://doi.org/10.1007/s12282-014-0554-y
Abstract
Most of the genome is transcribed to transcripts of no protein-coding potential. However, these transcripts do not represent transcriptional ‘noise’, rather they play an important role in cellular metabolism and development. Non-coding transcripts of 200 bases to 100 kb length are termed as long non-coding RNAs, majority of which are yet to be characterised thoroughly. Long non-coding RNAs (lncRNAs) play a significant role in cellular process ranging from transcriptional to post-transcriptional regulation. In this review, we highlight the recent efforts to characterise the major functions of lncRNAs in breast cancer. lncRNA expression is altered in several cancer types. Further, the aberrant regulation of lncRNAs promotes tumour development as they are involved in several cancer-associated pathways.Keywords
This publication has 71 references indexed in Scilit:
- Challenging paradigms: long non-coding RNAs in breast ductal carcinoma in situ (DCIS)Frontiers in Genetics, 2013
- Molecular Mechanisms of Long Noncoding RNAsMolecular Cell, 2011
- No-Nonsense Functions for Long Noncoding RNAsCell, 2011
- RNA–protein interactions in human health and diseaseSeminars in Cell & Developmental Biology, 2011
- The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor PhosphorylationMolecular Cell, 2010
- Evolution and Functions of Long Noncoding RNAsCell, 2009
- Origins and Mechanisms of miRNAs and siRNAsCell, 2009
- New twists in X-chromosome inactivationCurrent Opinion in Cell Biology, 2008
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007
- The non-coding Air RNA is required for silencing autosomal imprinted genesNature, 2002