OBSERVATIONS ON THE UREA CLEARANCE IN DOGS

Abstract

A modification of the method of Moller, McIntosh and Van Slyke, using 24-hr. clearances instead of the usual 2-hr. tests, is suggested. Data on normal dogs indicate that fasting may reduce the urea clearance to 25% or less. Dogs with Eck fistulas, with biliary obstruction, and with liver injury due to chloroform anesthesia showed low blood urea levels, at the time of greatest liver injury, which were reflected in a moderate rise of urea clearance above control levels.