Chemiluminescence determination of codeine by permanganate oxidation

Abstract

Codeine can be determined by a Flow injection procedure based on the chemiluminescence generated by reaction with potassium permanganate (6 × 10^–4 mol l^–1) in the presence of 0.5 mol l^–1 polyphosphoric acid. The limit of detection is 8 pmol (3 × 10^–7 mol l^–1 in a 25 µl sample), the relative standard deviation for the determination of 5 × 10^–4 mol l^–1 codeine is 1.4%(n= 10).