Action of inhibitors on monoamine and diamine metabolism in the rat

Abstract

The effects of a series of inhibitors of monoamine oxidase (EC 1.4.3.4) and diamine oxidase (EC 1.4.3.6) and of 2 chelating agents were studied in rats, with respect to the catabolism of labeled pentylamine and putrescine to radioactive CO2. D-Tranylcypromine, clorgyline, and deprenyl inhibited oxidation of the monoamine, with essentially no effect on putrescine, under the test conditions. Aminoguanidine inhibited putrescine but not pentylamine oxidation. Iproniazid, isoniazid and Lilly 51641 [N-2(chlorophenoxy)ethylcyclopropylamine hydrochloride] affected the catabolism of both amines. Pargyline inhibited putrescine oxidation, apparently in a reversible manner.