Acute Myeloid Leukemia After Single-Agent Treatment with Etoposide for Langerhansʼ Cell Histiocytosis of Bone

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Abstract
The first case of secondary leukemia (FAB M3 microgranular variant) after single-agent chemotherapy with etoposide is described. The peculiar morphology and the absence of previously described cytogenetic abnormalities make this case of interest and emphasize the need for further study of epipodophyllotoxin-related leukemia.