Inhibition of Spontaneous Contractile Activity in Isolated Human Detrusor Muscle Strips by Vasoactive Intestinal Polypeptide
- 1 February 1985
- journal article
- research article
- Published by Wiley in British Journal of Urology
- Vol. 57 (1), 20-23
- https://doi.org/10.1111/j.1464-410x.1985.tb08976.x
Abstract
In a study of 75 isolated human detrusor muscle strips [taken from the dome of the bladder at operation from patients with urodynamic abnormalities], spontaneous contractions and an associated sustained rise in basal tension were observed in 43 (57%). Vasoactive intestinal polypeptide (VIP) caused significant reductions in the frequency and amplitude of spontaneous contractions and a fall in basal tension. VIP may have a role as an inhibitor of spontaneous activity in the human detrusor.This publication has 8 references indexed in Scilit:
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- Human female bladder and its noncholinergic contractile functionCanadian Journal of Physiology and Pharmacology, 1983
- Distribution and motor effect of VIP in female genital tractAmerican Journal of Physiology-Endocrinology and Metabolism, 1981
- Effect of detrusor muscle length and tension on its response to pharmacologic and electrical stimulation Part II. In vitro studyUrology, 1980
- Effects of Prostaglandins on the Isolated Human Bladder and UrethraActa Physiologica Scandinavica, 1977