COMPOSITE TISSUE (LIMB) ALLOGRAFTS IN RATS

Abstract
Cyclosporine has reawakened interest in transplantation of peripheral composite tissue allografts (CTA) of skin, muscle, bone, vessel and nerves. Whether cyclosporine could produce indefinite survival of CTA was studied. Two groups of LEW recipients of LBN limb transplant were given different long-term treatments of cyclosporine. Tolerance was achieved in many of the animals. Several possibilities for the mechanism of this tolerance are discussed.