Generation of F1 hybrid cytotoxic T lymphocytes specific for self H–2
- 1 February 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 289 (5798), 559-563
- https://doi.org/10.1038/289559a0
Abstract
Cytotoxic T lymphocytes specific for self H-2 antigens are generated by murine F1 hybrid (H-2 heterozygous) spleen cells cultured with irradiated parental (H-2 homozygous) splenocytes. The effectors bind to heterozygous and homozygous cells bearing the appropriate H-2 alleles but only lyse homozygous targets. Autoreactivity for membrane-bound molecules of normal cells may be a mechanism for regulating cellular interactions.Keywords
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