Further Studies on the Question of an Inhibitory Hormone from the Gastric Antrum

Abstract

According to Babkin,¹ Sokolov, working in Pavlov's laboratory, discovered that in the dog the introduction of 0.5% of HCI into the stomach or of gastric juice into the duodenum markedly diminished the secretion of gastric juice from a Pavlov pouch. These observations were confirmed and extended by Wilhelmj and his associates^2-4 and led these authors to formulate the theory that when the gastric contents become sufficiently acid in reaction, the gastric phase of secretion is inhibited. This theory was strongly supported by experimental studies in this laboratory reported by Oberhelman, Woodward, Zubiran, and Dragstedt⁵ and by Woodward, Lyon, Landor, and Dragstedt.⁶ In dogs prepared with both the Heidenhain pouch and an isolated pouch of the antrum, the introduction of various foods into the isolated antrum provoked a vigorous secretion of gastric juice from the Heidenhain pouch. Distention of the isolated antrum also produced a copious secretion