Changes in Mouse Blood Pressure, Tumor Blood Flow, and Core and Tumor Temperatures following Nembutal or Urethane Anesthesia

Abstract

Female CBA and WHT mice with tumors transplanted into the right leg were immoblized in insulated capsules. Tumor blood flow, blood pressure and core and tumor temperatures were monitored prior to and during anesthesia with Nembutal or urethane. Nembutal caused a 5.degree. C drop in core and tumor temperatures in 20 min. Urethane induced a small fall in temperatures. Urethane initially caused a small drop in blood pressure followed by recovery, Nembutal caused a steady fall in blood pressure to 50% of resting value.