Brief Communication : Regression of Autochthonous Moloney Sarcoma Virus-Induced Tumors in Mice Treated With Polyriboinosinic Acid-Polyribocytidylic Acid 2

Abstract

NMRI mice infected neonatally with the Moloney strain of murine sarcoma virus (M-MSV) developed progressively growing tumors. These tumors did not regress and invariably killed the host. However, if these animals were treated repeatedly with polyriboinosinicpolyribocytidylic acid (poly I :C) on alternate days (from 40 to 60 days after M-MSV inoculation), 75% of the established tumors regressed. The exact mechanism of this marked stimulatory effect of poly I:C on tumor regression is not known.