In 1934 Goldblatt,1working in the physiologic laboratories at Western Reserve University, reported that partial constriction of the renal arteries of dogs was followed by a rise in blood pressure. Other observers previously had shown that hypertension was related to renal pathologic change, but no one ever had demonstrated it so graphically. Similar experiments were made subsequently in numerous laboratories, most of which confirmed the observations of Goldblatt. Seldom have physiologic experiments attracted such immediate, widespread interest in medical circles. The etiology and the treatment of hypertension have presented problems which have baffled medical science for long and it is not surprising that any suggestion as to the cause and amelioration of this disease would create general interest. It was not long before Goldblatt's experimental observations were confirmed by clinical reports2of cases in which the blood pressure of patients with hypertension returned to normal after removal of