Intracellular calcium and sodium in hypertensive patients.
- 1 March 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 9 (3), 224-229
- https://doi.org/10.1161/01.hyp.9.3.224
Abstract
Untreated subjects with mild to moderate hypertension were compared with normotensive controls recruited from the same ambulatory screening clinic. All subjects were black. Resting levels of cytosolic free calcium were estimated in washed platelets with the fluorescent intracellular probe fura 2, and sodium and potassium were measured in red blood cells. Calcium levels were 21% higher in the hypertensive subjects (p = 0.02), and a 9% increase in sodium was observed in an expanded sample (p = 0.04). Neither intracellular calcium nor intracellular sodium had a significant linear correlation with blood pressure when hypertensive subjects and controls were examined separately or when the two groups were combined. Potassium was slightly but not significantly increased in hypertensive subjects. Among the participants for whom both calcium and sodium measurements were available, a weak, nonsignificant correlation between these ions was noted (r = 0.2; n = 48). This correlation was significant among participants in the control group examined separately (r = 0.3; n = 33; p = 0.05). Although the measurements were performed in different cell lines, these findings demonstrate increases in both intracellular calcium and sodium in hypertensive humans.This publication has 37 references indexed in Scilit:
- Cellular Sodium Transport in Essential HypertensionNew England Journal of Medicine, 1986
- Associations of three erythrocyte cation transport systems with plasma lipids in Utah subjects.Hypertension, 1986
- Red cell cotransport activity and sodium content in black men. Relationship to essential hypertension.Hypertension, 1984
- Correlation of Platelet Calcium with Blood PressureNew England Journal of Medicine, 1984
- Plasma Digitalis-like Factor(s) Increase with Salt LoadingNew England Journal of Medicine, 1983
- Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.Hypertension, 1983
- Intracellular sodium and calcium in essential hypertensionKlinische Wochenschrift, 1982
- THE NATRIURETIC HORMONE AND ESSENTIAL HYPERTENSIONThe Lancet, 1982
- Circadian Rhythms of Blood Minerals in HumansScience, 1981
- Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential HypertensionNew England Journal of Medicine, 1980