The Role of Mobility in the Substrate Binding and Catalytic Machinery of Enzymes

Abstract
This chapter contains section titled: Enzymes As Machines Proteins are Flexible in the Crystalline State The Problem of Ligand Access The Problem of Response to Changing Substrate Structure When Tight Binding is Not So Tight Directed Fluctuations: Fact or Fantasy? Conclusion: Enzyme Mobility is Important for Enzyme Function References