Prostate Specific Antigen and Gleason Grade: An Immunohistochemical Study of Prostate Cancer

Abstract
Prostate cancer is histologically heterogeneous as reflected in the 5 patterns of the Gleason grading system. Gleason grade correlates with volume, extent and prognosis. Serum prostate specific antigen (PSA) levels also correlate with tumor volume but the degree to which grade correlates with PSA has not been precisely defined.