Recombinant Vaccinia Virus: Immunization Against Multiple Pathogens
- 6 September 1985
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 229 (4717), 981-984
- https://doi.org/10.1126/science.2992092
Abstract
The coding sequences for the hepatitis B virus surface antigen, the herpes simplex virus glycoprotein D, and the influenza virus hemagglutinin were inserted into a single vaccinia virus genome. Rabbits inoculated intravenously or intradermally with this polyvalent vaccinia virus recombinant produced antibodies reactive to all three authentic foreign antigens. In addition, the feasibility of multiple rounds of vaccination with recombinant vaccinia virus was demonstrated.Keywords
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