Reversible cholestasis with bile duct injury following azathioprine therapy. A case report
- 1 April 1991
- journal article
- case report
- Published by Wiley in Liver International
- Vol. 11 (2), 89-93
- https://doi.org/10.1111/j.1600-0676.1991.tb00497.x
Abstract
A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy. Liver biopsy showed cholestasis with both cytological and architectural alterations of interlobular bile ducts. Azathioprine withdrawal resulted after 7 weeks in the resolution of clinical and biochemical abnormalities. It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.Keywords
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