Polynucleotides. L. Synthesis and properties of poly (2′ - chloro - 2′ - deoxyadenylic acid) and poly (2′ - bromo - 2′ - deoxyadenylic acid)
- 1 January 1977
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 4 (12), 4249-4260
- https://doi.org/10.1093/nar/4.12.4249
Abstract
Poly (2'-chloro-2'-deoxyadenylic acid) and poly (2'-bromo-2'-deoxyadenylic acid) were synthesized from the corresponding diphosphates with the aid of polynucleotide phosphorylase from E. coli. UV, CD, acid titration and mixing with poly (U) were investigated. Comparing these properties with those of poly (A) and poly (2'-azido-2'-deoxyadenylic acid), it was found that 2''substituents exert significant effects on the thermal stability of these polynucleotides, though the overall conformational structure was not greatly changed.Keywords
This publication has 7 references indexed in Scilit:
- Polynucleotides. XLV1)Synthesis and properties of poly(2′-azido-2′-deoxyinosinic acid)Nucleic Acids Research, 1977
- Polynucleotides. XLVI.1Synthesis and properties of poly (2′-amino-2′-deoxyadenylic acid)Nucleic Acids Research, 1977
- Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acidNucleic Acids Research, 1976
- 2'-O-Alkyl polynucleotides. 2. Comparative studies on homopolymers of adenylic acid possessing different C-2' substituents of the furanose. Poly(deoxyriboadenylic acid), poly(riboadenylic acid), poly(2'-O-methyladenylic acid), and poly(2'-O-ethyladenylic acid)Biochemistry, 1974
- Substrate Specificity of Ribonuclease from Aspergillus saitoiThe Journal of Biochemistry, 1968
- Calculation of the optical rotatory dispersion of dinucleoside phosphatesJournal of Molecular Biology, 1967
- The molecular structure of polyadenylic acidJournal of Molecular Biology, 1961