Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.
Open Access
- 1 January 1980
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 151 (1), 246-251
- https://doi.org/10.1084/jem.151.1.246
Abstract
The mechanism of restriction of [mouse] T [thymus-derived] cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the non-thymic parental haplotype in naive cells adoptively transferred into chimeras suggested the existence of an in vivo suppressive mechanism. It was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.This publication has 17 references indexed in Scilit:
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