Cell surface expression of the metabotropic glutamate receptor type 1α is regulated by the C‐terminal tail

Abstract

The cell surface expression of metabotropic glutamate receptor type 1 splice variants has been studied using cell surface biotinylation. Co-expression of the last 86 residues of the C-terminal tail of mGluR1α (F2-protein) with mGluR1α caused a significant reduction of the amount of the cell surface receptor when compared to that in cells transfected with mGlur1α alone, and this was accompanied by a reduction in the production of inositol following agonist stimulation of the cells. In contrast, cell surface expression of mGluR1β was unaltered by co-expression with the F2-protein. These results suggest that the C-terminal tail of mGluR1α regulates cell surface expression of the receptor.