A Double-Blind Evaluation of Antihypertensive Drugs

Abstract

This statistically analyzed study was begun in January 1956. One group of patients received placebo and ergot alkaloids parenterally. Another group received ergot alkaloids, guanethidine, alpha-methyldopa, methysergide, spironolactone, and spironolactone and reserpine orally. Hypotensive effect of these agents is described. Parenteral placebo caused a significant decrease in systolic pressure for 139 weeks and in diastolic pressure for 179 weeks. Oral placebo in those with blood pressure less than 200/120 mm Hg caused no decrease, while those whose blood pressure exceeded 200/120 mm Hg sustained a decrease. Antihypertensive therapy is described. A statistical base line for evaluating antihypertensives is established.