Modulatory effects of the amygdala on oestrogen-induced LH secretion in ovariectomized rats

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Abstract
An increase in luteinizing hormone [LH] secretion was induced in ovariectomized estradiol benzoate-primed rats 5 h after a 2nd injection of estradiol benzoate. Lesions stereotaxically placed in the cortical and basomedial amygdala of steroid-primed rats abolished this rise. Evidently there is a facilitatory action of the amygdala upon LH release and an involvement of this region of the limbic system in estrogen-feedback mechanisms.