Synaptosomal adenosine triphosphatase (ATPase) inhibition by organophosphates
- 1 December 1976
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (12), 1540-1542
- https://doi.org/10.1007/bf01924440
Abstract
Chicken spinal cord adenosine triphosphatases (both Na+, K+ stimulated and ouabain insensitive) were inhibited by tri-o-tolyl phosphate (TOTP, a neurotoxic organophosphate which is not a cholinesterase inhibitor) and mevinphos (a non-neurotoxic compound but inhibitor of cholinesterases). The inhibition was concentration and time dependent, with an initial rapid drop in activity followed by a gradual exponential decline.Keywords
This publication has 15 references indexed in Scilit:
- Tissue cholinesterase inhibition by 2-carbomethoxy-I-methylvinyl dimethyl phosphate (mevinphos)Toxicology and Applied Pharmacology, 1973
- Effects of Soman and DFP in vivo and in vitro on cerebral metabolism in the ratBiochemical Pharmacology, 1971
- Effect of irreversible inhibitors on transport ATPaseArchives of Biochemistry and Biophysics, 1969
- Effects of some cholinesterase inhibitors on the squid giant axon—Their permeability, detoxication and effects on conduction and acetylcholinesterase activityBiochemical Pharmacology, 1969
- Distribution of sodium-plus-potassium-stimulated adenosine-triphosphatase activity in isolated nerve-ending particlesBiochemical Journal, 1965
- INHIBITION BY DIISOPROPYLFLUOROPHOSPHATE OF A KIDNEY TRANSPORT ADENOSINE TRIPHOSPHATASE BY PHOSPHORYLATION OF A SERINE RESIDUEProceedings of the National Academy of Sciences, 1964
- Sodium-stimulated adenosinetriphosphatase in microsomes from rat brainBiochimica et Biophysica Acta, 1961
- The influence of some cations on an adenosine triphosphatase from peripheral nervesBiochimica et Biophysica Acta, 1957
- Experimental demyelination with organo‐phosphorus compoundsThe Journal of Pathology and Bacteriology, 1953
- Determination of Inorganic PhosphateAnalytical Chemistry, 1949