Telomere directed fragmentation of mammalian chromosomes
- 1 January 1993
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 21 (1), 27-36
- https://doi.org/10.1093/nar/21.1.27
Abstract
Cloned human telomeric DNA can integrate into mammalian chromosomes and seed the formation of new telomeres. This process occurs efficiently in three established human cell lines and in a mouse embryonic stem cell line. The newly seeded telomeres appear to be healed by telomerase. The seeding of new telomeres by cloned telomeric DNA is either undetectable or very inefficient in non-tumourigenic mouse or human somatic cell lines. The cytogenetic consequences of the seeding of new telomeres include large chromosome truncations but most of the telomere seeding events occur close to the pre-existing ends of natural chromosomes.Keywords
This publication has 17 references indexed in Scilit:
- Mammalian artificial chromosomesCurrent Opinion in Genetics & Development, 1992
- Structure and polymorphism of human telomere-associated DNACell, 1990
- Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usageCell, 1990
- The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeatsCell, 1989
- Isolation and characterization of a multipotent clone of human embryonal carcinoma cellsDifferentiation, 1989
- Physical mapping of large DNA by chromosome fragmentation.Proceedings of the National Academy of Sciences, 1988
- Mapping of the oncogenes Myc, Sis, and int-1 to the distal part of mouse chromosome 15Cytogenetic and Genome Research, 1987
- Construction of telocentric chromosomes in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences, 1985
- Expression of a Bacterial Gene in Mammalian CellsScience, 1980
- STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSESThe Journal of Experimental Medicine, 1953