A population study of the long-term consequences of Rose angina: 20-year follow-up of the Renfrew-Paisley study

Abstract

Objective: To examine the long-term cardiovascular consequences of angina in a large epidemiological study. Design: Prospective cohort study conducted between 1972 and 1976 with 20 years of follow-up (the Renfrew–Paisley Study). Setting: Renfrew and Paisley, West Scotland, UK. Participants: 7048 men and 8354 women aged 45–64 years who underwent comprehensive cardiovascular screening at baseline, including the Rose Angina Questionnaire and electrocardiography (ECG). Main outcome measures: All deaths and hospitalisations for cardiovascular reasons occurring over the subsequent 20 years, according to the baseline Rose angina score and baseline ECG. Results: At baseline, 669 (9.5%) men and 799 (9.6%) women had angina on Rose Angina Questionnaire. All-cause mortality for those with Rose angina was 67.7% in men and 43.3% in women at 20 years compared with 45.4% and 30.4%, respectively, in those without angina (pConclusions: Angina in middle age substantially increases the risk of death, myocardial infarction, heart failure and other cardiovascular events.